Unlock the Full Potential of Your Omics Data

Expert biostatistics consulting for genomics, transcriptomics, proteomics, and multi-omics integration

RNA-Seq Single-cell Sequencing Spatial Transcriptomics Proteomics Metabolomics Whole-Genome Association Studies (WGAS) Multi-omics Integration and more ..
Dr. Gregory R. Warnes

Stop Drowning in Data. Start Discovering.

Transform complex omics datasets into actionable biological insights

Core Services

Experimental Design & Power Analysis

Optimal experimental design, power calculations, and cost vs quality balance to ensure your study succeeds from the start.

Advanced Statistical Analysis

Differential expression, isoform usage, spatial pattern detection, trajectory analysis, and pathway enrichment using state-of-the-art methods.

Multi-omics Integration

Seamless integration of transcriptomics, proteomics, metabolomics, and other omics layers with rigorous batch-effect correction.

Publication-Quality Visualizations

Stunning, publication-ready figures: volcano plots, heatmaps, UMAP/t-SNE, spatial maps, pseudotime trajectories, and more.

Biological Interpretation

Clear, narrative-driven interpretation that connects statistical findings to biological mechanisms and research questions.

Pipeline Development

Reproducible, automated analysis pipelines tailored to your specific data types and research needs.

Gregory R. Warnes, Ph.D.

Expert Biostatistics Consulting

Ph.D. in Biostatistics

University of Washington, Seattle

20+ Years of Expertise

Biostatistics, genomics, and high-dimensional biomedical data

Open Source Contributor

Developer of 20+ widely-used R packages (genetics, gplots, gmodels, gtools, gdata, and more)

BioPharm Industry and Academic Experience

Pfizer, Novartis, Boehringer Ingelheim, Medidata Solutions

University of Rochester, Yale University

Proven Track Record

Helping labs design smarter experiments and publish stronger results across academia and industry. 65+ LinkedIn endorsements

Dr. Gregory R. Warnes

Areas of Expertise

Genomics & Transcriptomics

  • RNA-Seq (bulk and single-cell)
  • Spatial transcriptomics
  • ChIP-Seq and epigenetics
  • GWAS and variant analysis
  • Gene expression profiling
  • Isoform detection and quantification

Statistical Methods

  • Differential expression analysis
  • Pathway enrichment analysis
  • Trajectory and pseudotime analysis
  • Batch effect correction
  • Dimensionality reduction (PCA, UMAP, t-SNE)
  • Mixed-effects models

Multi-omics Integration

  • Transcriptomics + Proteomics
  • Metabolomics integration
  • Systems biology approaches
  • Network analysis
  • Multi-modal data fusion
  • Cross-platform normalization

Technical Skills

  • R & Bioconductor (expert)
  • Python & scikit-learn
  • Machine learning & AI
  • Cloud computing (AWS, GCP)
  • Workflow automation
  • Database management

Industry Experience

  • Pharmaceutical R&D (Pfizer, Novartis, Boehringer Ingelheim)
  • Clinical trial analysis (Medidata, CDISC standards)
  • Drug discovery and target validation
  • Biomarker discovery
  • Precision medicine

Academic Collaboration

  • Experimental design consultation
  • Grant proposal support
  • Manuscript preparation
  • Statistical review
  • Methods development
  • Training and workshops

Publication-Quality Visualizations

Example data visualizations

Gene Expression Heatmap

Gene Expression Heatmap

Hierarchical clustering of differential expression patterns across experimental conditions

Volcano Plot

Volcano Plot Analysis

Statistical significance vs. fold-change visualization for identifying key biomarkers

UMAP Plot

Single-Cell UMAP

Dimensionality reduction revealing distinct cell populations and trajectories

Pathway Enrichment

Pathway Enrichment Analysis

GO term and KEGG pathway analysis with statistical significance

Expression Analysis

Treatment Response Analysis

Target gene expression across experimental conditions with statistical testing

GWAS Manhattan Plot - MLXIPL

Genome-Wide Association Study

Manhattan plot showing association between MLXIPL variation and plasma triglycerides

From: Kooner JS, Chambers JC, Aguilar-Salinas CA, et al. (2008) "Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides." Nature Genetics 40:149-151. doi:10.1038/ng.2007.61

Visualizations: Includes both example analyses and figures from peer-reviewed publications demonstrating real-world applications of genomic data analysis. Each project receives custom visualizations tailored to your specific research questions and data types.

"Proven track record of helping labs design smarter experiments and publish stronger results"

25+ Years of Experience
100+ Projects Completed
20+ Open Source R Packages
7,298+ Citation Count

Selected Publications & Software

Peer-reviewed publications and open-source contributions in biostatistics, genomics, and statistical computing

Patents

Method and apparatus for transmission and reception of a signal over multiple frequencies with time offset encoding at each frequency
Warnes, GR
US Patent 9,602,228, 2017
View Patent

Selected Peer-Reviewed Publications

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides in man
Kooner JS, Chambers JC, Aguilar-Salina CA, et al.
Nature Genetics, 40, 149-151 (2008)
Read Article
DEDiscover: A Computation and Simulation Tool for HIV Viral Fitness Research
Hulin Wu, Hongyu Miao, Warnes GR, Canglin Wu, LeBlanc A, Dykes C, Demeter LM
BioMedical Engineering and Informatics, BMEI 2008, vol.1, pp.687-694 (2008)
Read Article
Statistical Modeling of Biochemical Pathways
Burrows RB, Warnes GR, Hanumara RC
IET Systems Biology, IET Syst. Biol. 1, 353 (2007)
Read Article
Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes
Mank-Seymour AR, Richmond JL, Wood LS, Reynolds JM, Fan Y, Warnes GR, Milos MP, Thompson JF
American Heart Journal, Volume 152, Issue 6, Pages 1116-1122 (2006)
Read Article
Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae
Caba E, Dickinson DA, Warnes GR, Aubrecht J
Mutation Research, Volume 575, Issues 1-2, Pages 34-46 (2005)
Read Article
Differentiation of DNA-reactive and non-reactive genotoxic mechanisms using gene expression profile analysis
Dickinson DA, Warnes GR, Quievryn G, Messer J, Zhitkovich A, Rubitski E, Jiri A
Mutation Research, Volume 549, Issues 1-2, Pages 29-41 (2004)
Read Article
HYDRA: A Java library for Markov Chain Monte Carlo
Warnes GR
Journal of Statistical Software, Volume 7, Issue 4 (2002)
Read Article
A Univariate Measurement Error Model for Longitudinal Change
Yanez ND, Warnes GR, Kronmal RA
Communications in Statistics, Volume 30, Issue 2 (2001)
Read Article

Key Open Source Software (R Packages)

gplots
Programming tools for plotting data in R
CRAN
genetics
Classes and methods for handling genetic marker data
CRAN
gmodels
Various programming tools for model fitting
CRAN
gtools
Various general purpose R programming tools
CRAN
gdata
Programming tools for data manipulation
CRAN
ssize
Sample size calculation for microarray experiments
Bioconductor
GeneticsQC
Quality control for genetic data sets
R-Genetics
SASxport
Read and write SAS XPORT format files
CRAN

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